The influence of slip on the peristaltic motion of a third order fluid in an asymmetric channel

In this investigation, the peristaltic flow of a third order fluid in an asymmetric channel is considered in the presence of a slip condition. The series solution of the stream function and longitudinal pressure gradient is given under long wave length and low Reynolds number approximations. Pressure rise and frictional forces per wave length are analyzed through numerical integration. Pumping and trapping phenomena are examined and the obtained results are compared with those of no-slip condition. Comparison is made with the results of no-slip and viscous fluid cases.     

Structural,compositional and hardness properties of hydrogenated amorphous carbon nitride thin films synthesized by dense plasma focus device

The hydrogenated amorphous carbon nitride (a‐CN_x:H) thin films were synthesized on the SS‐304 substrates using a dense plasma focus device. The a‐CN_x:H thin films were synthesized using CH₄/N₂ admixture gas and 20 focus deposition shots on substrates placed at different distances from the anode top. X‐ray photoelectron spectroscopy and Raman analysis confirmed different C–N bonding in the a‐CN_x:H thin films. A decrease in the N/C ratio as well as the sp³/sp² ratio with an increase in the substrate distance has been observed. The higher amount of C–N formation for the film synthesized at 10 cm is observed which decreases with increasing distance. The X‐ray photoelectron spectroscopy and Raman analysis affirmed the C ≡ N presence in all the thin films synthesized at different distances. The morphology of the synthesized a‐CN_x:H thin films showed nanoparticles and nanoparticle clusters formation at the surface. The hardness results showed comparatively lower hardness of the a‐CN_x:H thin films due to the presence of C ≡ N. The C–N formation with lower amount of C ≡ N and a higher N/C ratio as well as a higher sp³/sp² ratio for the films synthesized at 10 cm show reasonably higher hardness. Copyright © 2016 John Wiley & Sons, Ltd.     

Two New Disulfated Triterpenoids from Zygophyllum fabago

From the aerial parts of Zygophyllum fabago, two new monosodium salts of sulfated derivatives of ursolic acid, along with two known quinovic acid glycosides were isolated. The structures of the new compounds were determined as (3β,4α)‐3,23,30‐trihydroxyurs‐20‐en‐28‐al 3,23‐di(sulfate) sodium salt (1 : 1) ( 1 ) and of (3β,4α)‐3,23,28‐trihydroxyurs‐20‐en‐30‐yl β‐D ‐glucopyranoside 3,23‐di(sulfate) sodium salt (1 : 1) ( 2 ) with the molecular formula C₃₀H₄₇NaO₁₀S₂ and C₃₆H₅₉NaO₁₅S₂, respectively. The structures of the known compounds were 3‐O‐(2‐O‐sulfo‐β‐D ‐quinovopyranosyl)quinovic acid 28‐β‐D ‐glucopyranosyl ester ( 3 ) and 3‐O‐(β‐D ‐glucopyranosyl)quinovic acid 28‐β‐D ‐glucopyranosyl ester ( 4 ) (quinovic acid=(3β)‐3‐hydroxyurs‐12‐ene‐27,28‐dioic acid). The structures of all these compounds were determined by using 1D‐ and 2D‐NMR spectroscopic techniques.     

Influence of slip condition on the peristaltic transport in an asymmetric channel with heat transfer: An exact solution

The mechanism of peristaltic magnetohydrodynamic (MHD) flow based on slip and heat transfer effects is studied in an asymmetric channel. An incompressible viscous fluid fills the porous space inside the channel. Long wavelength and zero Reynolds number approximation are used in the flow modeling. Expressions of stream function, longitudinal pressure gradient, and temperature are developed. Various interesting phenomena associated with peristalsis, such as pumping and trapping, are discussed in detail. Further the effects of various pertinent parameters on temperature field and heat transfer coefficient are explained with the help of graphs and tables. It is found that pressure rise over one wavelength decreases in pumping region for large values of slip parameter. Similar behavior is observed for temperature field by increasing the slip parameter. However, the volume of trapped bolus decreases by increasing the slip parameter. Copyright © 2010 John Wiley & Sons, Ltd.     

Effect of alkaline pretreatment on delignification of wheat straw

This study was conducted to analyse structural changes through scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) after alkaline pretreatment of wheat straw for optimum steaming period. During the study, 2 mm size of substrate was soaked in 2.5% NaOH for 1 h at room temperature and then autoclaved at 121°C for various steaming time (30, 60, 90 and 120 min). Results revealed that residence time of 90 min at 121°C has strong effect on substrate, achieving a maximum cellulose content of 83%, delignification of 81% and hemicellulose content of 10.5%. Further SEM and FTIR spectroscopy confirmed structural modification caused by alkaline pretreatment in substrate. Maximum saccharification yield of 52.93% was achieved with 0.5% enzyme concentration using 2.5% substrate concentration for 8 h of incubation at 50°C. This result indicates that the above-mentioned pretreatment conditions create accessible areas for enzymatic hydrolysis.     

Identification,control strategies,and analytical approaches for the determination of potential genotoxic impurities in pharmaceuticals: A comprehensive review

Potential genotoxic impurities in pharmaceuticals at trace levels are of increasing concern to both pharmaceutical industries and regulatory agencies due to their possibility for human carcinogenesis. Molecular functional groups that render starting materials and synthetic intermediates as reactive building blocks for small molecules may also be responsible for their genotoxicity. Determination of these genotoxic impurities at trace levels requires highly sensitive and selective analytical methodologies, which poses tremendous challenges on analytical communities in pharmaceutical research and development. Experimental guidance for the analytical determination of some important classes of genotoxic impurities is still unavailable in the literature. Therefore, the present review explores the structural alerts of commonly encountered potential genotoxic impurities, draft guidance of various regulatory authorities in order to control the level of impurities in drug substances and to assess their toxicity. This review also describes the analytical considerations for the determination of potential genotoxic impurities at trace levels and finally few case studies are also discussed for the determination of some important classes of potential genotoxic impurities. It is the authors’ intention to provide a complete strategy that helps analytical scientists for the analysis of such potential genotoxic impurities in pharmaceuticals.     

Photocatalysed degradation of a herbicide derivative, Dinoterb, in aqueous suspension

The photocatalytic degradation of a herbicide derivative, Dinoterb (1), has been investigated in aqueous micellar solution in the presence of titanium dioxide (TiO₂) and air as a function of irradiation time under a variety of conditions using UV and HPLC analysis techniques. The degradation kinetics was studied under different conditions such as different types of TiO₂, catalyst concentration, substrate concentration and reaction pH in the presence of air. The photocatalyst Degussa P25 was found to be more efficient catalyst as compared to other photocatalysts tested. The model compound was found to degrade more efficiently under neutral pH as compared to acidic and alkaline pH. GC/MS analysis of the irradiated samples indicate the formation of 2-isopropyl-4,6-dinitro-phenol as by-product which has been characterized on the basis of molecular ion and mass fragmentation pattern. A probable pathway for its formation has been proposed.     

Highly sensitive hydrazine chemical sensor based on mono-dispersed rapidly synthesized PEG-coated ZnS nanoparticles

Monodispersed PEG-coated ZnS (P-ZnS) nanoparticles (NPs) were synthesized by facile microwave process and utilized as efficient electron mediators for the fabrication of highly sensitive hydrazine chemical sensor. The detailed morphological and structural properties revealed the monodispersity and good crystallinity for synthesized P-ZnS NPs. A high-sensitivity of ∼89.3 μA cm⁻² μM and low limit of detection of 1.07 μM, based on S/N ratio, were obtained for the fabrication of hydrazine chemical sensor based on P-ZnS NPs. To the best of our knowledge, this is the first report which demonstrates the utilization of P-ZnS NPs for the fabrication of efficient hydrazine chemical sensor. By this work, it could be concluded that simply synthesized ZnS NPs can be used as efficient electron mediators for the fabrication of effective hydrazine chemical sensors.